Synthesis and preliminary biological study of bisindolylmethanes accessed by an acid-catalyzed hydroarylation of vinyl indoles
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چکیده
منابع مشابه
Synthesis and preliminary biological studies of 3-substituted indoles accessed by a palladium-catalyzed enantioselective alkene difunctionalization reaction.
A unique alkene difunctionalization reaction that allows rapid construction of molecular complexity around the biologically relevant indole framework has been developed. The reaction proceeds with up to 87% yield, 99:1 er, and >20:1 dr. Evaluation of several of the compounds revealed promising anticancer activity against MCF-7 cells.
متن کاملPalladium-catalyzed synthesis of N-vinyl pyrroles and indoles.
A stereospecific palladium-catalyzed N-vinylation of azaheterocycles with vinyl triflates is described. Cyclic and acyclic vinyl triflates along with nonnucleophilic azaheterocycles were found to be substrates for this palladium-catalyzed synthesis of N-vinyl pyrrole and indole derivatives.
متن کاملPlatinum(II)-catalyzed intermolecular hydroarylation of unactivated alkenes with indoles.
Ethylene, alpha-olefins, and vinyl arenes undergo platinum-catalyzed hydroarylation with substituted indoles in moderate to good yield.
متن کاملGold-catalyzed synthesis of tetrahydrocarbazole derivatives through an intermolecular cycloaddition of vinyl indoles and N-allenamides.
A gold-catalyzed formal [4+2] cycloaddition of vinyl indoles and N-allenamides leading to tetrahydrocarbazoles is described. Moreover, new multicomponent reactions of vinyl indoles with two allene molecules are reported.
متن کاملSynthesis of Fused Polycyclic Indoles by Brønsted Acid-Catalyzed Intramolecular Alkylation of Indoles with Alcohols.
An efficient methodology for the synthesis of a series of new fused polyclyclic indoles has been developed by Brønsted acid-catalyzed intramolecular Friedel-Crafts reactions of properly designed indolyl alcohols.
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2012
ISSN: 0040-4020
DOI: 10.1016/j.tet.2012.03.075